apalutamide will decrease the extent or impact of diazepam by impacting hepatic enzyme CYP2C19 metabolism. Avoid or Use Alternate Drug. Coadministration of apalutamide, a robust CYP2C19 inducer, with medications which have been CYP2C19 substrates can result in lower publicity to these medicines.Influence of coadministration of a dual CYP3A4 and CYP